PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival.

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第一作者： YoneJung,Yoon

第一单位： Center for Molecular Biology and Genetics of Neurodegeneration, Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

作者： YoneJung,Yoon ^[1] ; Georgios,Voloudakis ^[2] ; Nathan,Doran ^[1] ; Emily,Zhang ^[3] ; Christina,Dimovasili ^[1] ; Lei,Chen ^[1] ; Zhiping,Shao ^[1] ; Spyros,Darmanis ^[4] ; Cheuk,Tang ^[3] ; Jun,Tang ^[5] ; Victoria X,Wang ^[6] ; Patrick R,Hof ^[6] ; Nikolaos K,Robakis ^[7] ; Anastasios,Georgakopoulos ^[8]

作者单位： Center for Molecular Biology and Genetics of Neurodegeneration, Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[1] Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[2] Pamela Sklar Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[3] Department of Physiology, Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, 40536, USA. ^[4] Departments of Bioengineering and Applied Physics, Stanford University and Chan Zuckerberg Biohub, Stanford, CA, 94305, USA. ^[5] Department of Radiology, Neuroscience and Psychiatry Translational and Molecular Imaging Institute at Mount Sinai, New York, NY, USA. ^[6] Department of Radiology, Translational and Molecular Imaging Institute at Mount Sinai, New York, NY, USA. ^[7] Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[8] Center for Molecular Biology and Genetics of Neurodegeneration, Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Nikos.Robakis@mssm.edu. ^[9] Center for Molecular Biology and Genetics of Neurodegeneration, Departments of Psychiatry and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Tassos.Georgakopoulos@mssm.edu. ^[10]