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首页> Theranostics> Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway.

Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway.

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第一作者： Bing,Yan

第一单位： Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Suzhou, Jiangsu 215123, P. R. China.

作者： Bing,Yan ^[1] ; Yu,Zhang ^[1] ; Chun,Liang ^[2] ; Bin,Liu ^[3] ; Fengzhi,Ding ^[1] ; Yanli,Wang ^[1] ; Bao,Zhu ^[1] ; Ranzun,Zhao ^[4] ; Xi-Yong,Yu ^[5] ; Yangxin,Li ^[1]

作者单位： Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Suzhou, Jiangsu 215123, P. R. China. ^[1] Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P. R. China. ^[2] Department of Cardiology, the Second Hospital of Jilin University, Changchun, Jilin 130041, P. R. China. ^[3] The First Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, P. R. China. ^[4] Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 511436, P. R. China. ^[5]

关键词 NLRP3 circRNA exosome inflammasome pyroptosis

主题词动物(Animals);细胞系(Cell Line);疾病模型, 动物(Disease Models, Animal);外泌体(Exosomes);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);缺血(Ischemia);男(雄)性(Male);间质干细胞移植(Mesenchymal Stem Cell Transplantation);间质干细胞(Mesenchymal Stem Cells);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);微RNAs(MicroRNAs);脐带(Umbilical Cord)

DOI 10.7150/thno.42259

PMID 32550900

发布时间 2021-12-04

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Theranostics

Theranostics

2020年10卷15期

6728-6742页

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