Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells.

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第一作者： Yuan,Hao

第一单位： Channing Division of Network Medicine and.

作者： Yuan,Hao ^[1] ; Samuel,Bates ^[1] ; Hongmei,Mou ^[2] ; Jeong H,Yun ^[1] ; Betty,Pham ^[1] ; Jiangyuan,Liu ^[1] ; Weiliang,Qiu ^[1] ; Feng,Guo ^[1] ; Jarrett D,Morrow ^[1] ; Craig P,Hersh ^[1] ; Christopher J,Benway ^[1] ; Lu,Gong ^[1] ; Yihan,Zhang ^[2] ; Ivan O,Rosas ^[3] ; Michael H,Cho ^[1] ; Jin-Ah,Park ^[4] ; Peter J,Castaldi ^[1] ; Fei,Du ^[1] ; Xiaobo,Zhou ^[1]

作者单位： Channing Division of Network Medicine and. ^[1] Mucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts; and. ^[2] Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. ^[3] Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. ^[4]

关键词 CRISPR/Cas9 genome-editing DSP bronchial epithelial cells cell migration rs2076295

主题词桥粒斑蛋白质类(Desmoplakins);上皮细胞(Epithelial Cells);基因表达(Gene Expression);遗传变异(Genetic Variation);全基因组关联研究(Genome-Wide Association Study);人类(Humans);特发性肺纤维化(Idiopathic Pulmonary Fibrosis)

DOI 10.1164/rccm.201910-1958OC

PMID 32551799

发布时间 2024-08-03

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