G9a regulates tumorigenicity and stemness through genome-wide DNA methylation reprogramming in non-small cell lung cancer.

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作者： Rajendra P,Pangeni ^[1] ; Lu,Yang ^[2] ; Keqiang,Zhang ^[3] ; Jinhui,Wang ^[4] ; Wendong,Li ^[3] ; Chao,Guo ^[4] ; Xinwei,Yun ^[5] ; Ting,Sun ^[3] ; Jami,Wang ^[6] ; Dan J,Raz ^[3]

作者单位： Division of Thoracic Surgery, City of Hope National Medical Center, Duarte, CA, 91010, USA. rpangeni@coh.org. ^[1] Department of System Biology, Beckman Research Institute, City of Hope National Medical Centre, Duarte, CA, USA. ^[2] Division of Thoracic Surgery, City of Hope National Medical Center, Duarte, CA, 91010, USA. ^[3] The Integrative Genomics Core Lab, Department of Molecular Medicine, City of Hope National Medical Center, Duarte, CA, USA. ^[4] Frey Medical Laboratory, Maoling Rd, Jinan District, Fuzhou, Fujian, China. ^[5] Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China. ^[6] Western University of Health Sciences, Pomona, CA, USA. ^[7] Division of Thoracic Surgery, City of Hope National Medical Center, Duarte, CA, 91010, USA. draz@coh.org. ^[8]

关键词 DNA RNA sequencing Epigenetic regulation G9A Genome-wide methylation array NSCLC Stemness TICs Therapeutic approach