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Partitioning of cancer therapeutics in nuclear condensates.

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作者单位: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. [1] Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [3] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. [4] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. [5] Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [6] Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [7] Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. [8] Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA. [9] Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany. [10] Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany. [11] Center for Systems Biology Dresden, 01307 Dresden, Germany. [12] Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA. [13] Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [14] Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [15] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [16] Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard Medical School, Cambridge, MA 02139, USA. [17] Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [18] Department of Chemistry, Pohang University of Science and Technology, and Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 37673, Republic of Korea. [19] Cluster of Excellence Physics of Life, Technical University of Dresden, 01062 Dresden, Germany. [20] Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. young@wi.mit.edu. [21]
DOI 10.1126/science.aaz4427
PMID 32554597
发布时间 2024-03-30
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