Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress.

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第一作者： Xiang,Cheng

第一单位： Department of Radiation Oncology, James Comprehensive Cancer Center and College of Medicine at The Ohio State University, Columbus, OH 43210, USA.

作者： Xiang,Cheng ^[1] ; Feng,Geng ^[1] ; Meixia,Pan ^[2] ; Xiaoning,Wu ^[1] ; Yaogang,Zhong ^[1] ; Chunyan,Wang ^[2] ; Zhihua,Tian ^[1] ; Chunming,Cheng ^[1] ; Rui,Zhang ^[1] ; Vinay,Puduvalli ^[3] ; Craig,Horbinski ^[4] ; Xiaokui,Mo ^[5] ; Xianlin,Han ^[6] ; Arnab,Chakravarti ^[1] ; Deliang,Guo ^[7]

作者单位： Department of Radiation Oncology, James Comprehensive Cancer Center and College of Medicine at The Ohio State University, Columbus, OH 43210, USA. ^[1] Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. ^[2] Division of Neuro-Oncology, Department of Neurology, The Ohio State University, Columbus, OH 43210, USA. ^[3] Departments of Pathology and Neurosurgery, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611, USA. ^[4] Biostatistic Center and Department of Bioinformatics, College of Medicine at The Ohio State University, Columbus, OH 43210, USA. ^[5] Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. ^[6] Department of Radiation Oncology, James Comprehensive Cancer Center and College of Medicine at The Ohio State University, Columbus, OH 43210, USA; Center for Cancer Metabolism, James Comprehensive Cancer Center at The Ohio State University, Columbus, OH 43210, USA. Electronic address: deliang.guo@osumc.edu. ^[7]

关键词 DGAT1 ROS acylcarnitine fatty acids glioblastoma lipid droplets lipotoxicity mitochondria oxidative stress triglycerides