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In Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment.

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第一作者： Filip,Rosa

第一单位： Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.

作者： Filip,Rosa ^[1] ; Ashutosh,Dhingra ^[2] ; Betül,Uysal ^[1] ; G Dulini C,Mendis ^[3] ; Heidi,Loeffler ^[1] ; Gina,Elsen ^[1] ; Stephan,Mueller ^[1] ; Niklas,Schwarz ^[1] ; Melissa,Castillo-Lizardo ^[2] ; Claire,Cuddy ^[3] ; Felicitas,Becker ^[1] ; Peter,Heutink ^[4] ; Christopher A,Reid ^[3] ; Steven,Petrou ^[3] ; Holger,Lerche ^[5] ; Snezana,Maljevic ^[6]

作者单位： Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. ^[1] Genome Biology of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany. ^[2] The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia. ^[3] Genome Biology of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany; Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. ^[4] Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. Electronic address: holger.lerche@uni-tuebingen.de. ^[5] Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany; The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia. Electronic address: snezana.maljevic@florey.edu.au. ^[6]

关键词 NGN2 development disease modeling dual SMAD electrophysiology human neurons iPSCs ion channels neuronal network activity oscillations