Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells in a cell line model.

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第一作者： Vince Kornél,Grolmusz

第一单位： Department of Medical Oncology and Therapeutics Research, Beckman Research Institute, City of Hope National Medical Center, 1218 S Fifth Ave, Monrovia, CA 91016 USA.

作者： Vince Kornél,Grolmusz ^[1] ; Jinfeng,Chen ^[1] ; Rena,Emond ^[1] ; Patrick A,Cosgrove ^[1] ; Lance,Pflieger ^[1] ; Aritro,Nath ^[1] ; Philip J,Moos ^[2] ; Andrea H,Bild ^[1]

作者单位： Department of Medical Oncology and Therapeutics Research, Beckman Research Institute, City of Hope National Medical Center, 1218 S Fifth Ave, Monrovia, CA 91016 USA. ^[1] Department of Pharmacology and Toxicology, University of Utah, 30 S 2000 East, Salt Lake City, UT 84112 USA. ^[2]

关键词 CDK4/6 inhibitor Collateral sensitivity Drug resistance Tumor heterogeneity Wee-1-inhibitor

DOI 10.1186/s12935-020-01337-1

PMID 32565737

发布时间 2022-04-15

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