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首页> The Journal of biological chemistry> Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2).

Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2).

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作者： Jamie A,Kelly ^[1] ; Alexandra N,Olson ^[1] ; Krishna,Neupane ^[2] ; Sneha,Munshi ^[2] ; Josue,San Emeterio ^[3] ; Lois,Pollack ^[4] ; Michael T,Woodside ^[5] ; Jonathan D,Dinman ^[6]

作者单位： Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA. ^[1] Department of Physics, University of Alberta, Edmonton, Alberta, Canada. ^[2] School of Applied and Engineering Physics, Cornell University, Ithaca, New York, USA. ^[3] School of Applied and Engineering Physics, Cornell University, Ithaca, New York, USA lp26@cornell.edu mwoodsid@ualberta.ca dinman@umd.edu. ^[4] Department of Physics, University of Alberta, Edmonton, Alberta, Canada lp26@cornell.edu mwoodsid@ualberta.ca dinman@umd.edu. ^[5] Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA lp26@cornell.edu mwoodsid@ualberta.ca dinman@umd.edu. ^[6]

关键词 (+) ssRNA RNA RNA structure coronavirus coronavirus disease 2019 (COVID-19)inhibitor mRNA pseudoknot programmed ?1 ribosomal frameshifting (?1 PRF)small molecule inhibitor translation virus

主题词冠状病毒感染(Coronavirus Infections);药物设计(Drug Design);移码, 核糖体(Frameshifting, Ribosomal);基因表达调控, 病毒(Gene Expression Regulation, Viral);人类(Humans);疾病大流行(Pandemics);肺炎, 病毒性(Pneumonia, Viral);RNA, 病毒(RNA, Viral);病毒复制(Virus Replication)

DOI 10.1074/jbc.AC120.013449

PMID 32571880

发布时间 2024-09-22

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The Journal of biological chemistry

The Journal of biological chemistry

2020年295卷31期

10741-10748页

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