Dually Enzyme- and Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy.

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作者： Na,Yu ^[1] ; Tao,Liu ^[1] ; Xi,Zhang ^[1] ; Ningqiang,Gong ^[2] ; Tianjiao,Ji ^[3] ; Jing,Chen ^[2] ; Xing-Jie,Liang ^[2] ; Daniel S,Kohane ^[4] ; Shutao,Guo ^[3]

作者单位： Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China. ^[1] Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing 100190, China. ^[2] Laboratory for Biomaterials and Drug Delivery, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, United States. ^[3] University of Chinese Academy of Sciences, Beijing 100049, China. ^[4]

关键词 Cancer Therapy Glycosides Nanomedicines Prodrugs pH-Sensitive

主题词动物(Animals);糖苷类(Glycosides);小鼠(Mice);钠米医学(Nanomedicine);纳米粒子(Nanoparticles);肿瘤(Neoplasms);药物前体(Prodrugs)

DOI 10.1021/acs.nanolett.0c01973

PMID 32573235

发布时间 2021-06-24

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