SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites.

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作者： Liwen,Zhou ^[1] ; Lisi,Zheng ^[1] ; Kaishun,Hu ^[2] ; Xin,Wang ^[1] ; Ruhua,Zhang ^[1] ; Yezi,Zou ^[1] ; Li,Zhong ^[1] ; Shang,Wang ^[1] ; Yuanzhong,Wu ^[3] ; Tiebang,Kang ^[4]

作者单位： Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China. ^[1] Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. ^[2] Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China. wuyzh@sysucc.org.cn. ^[3] Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China. kangtb@sysucc.org.cn. ^[4]

主题词半胱氨酸内肽酶类(Cysteine Endopeptidases);DNA断裂, 双链(DNA Breaks, Double-Stranded);DNA损伤(DNA Damage);酯类(Esters);黄酮类(Flavones);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);肿瘤(Neoplasms);活化STAT的蛋白抑制物(Protein Inhibitors of Activated STAT);蛋白质加工, 转译后(Protein Processing, Post-Translational);吡唑类(Pyrazoles);嘧啶类(Pyrimidines);辐射, 电离(Radiation, Ionizing);磺酸类(Sulfonic Acids);SUMO化(Sumoylation);细胞因子信号转导蛋白抑制因子(Suppressor of Cytokine Signaling Proteins);泛素缀合酶类(Ubiquitin-Conjugating Enzymes)

DOI 10.1038/s41392-020-0172-4

PMID 32576812

发布时间 2021-10-07

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Signal transduction and targeted therapy

2020年5卷1期

80页

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SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites.

Signal transduction and targeted therapy

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Signal transduction and targeted therapy

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SUMOylation stabilizes hSSB1 and enhances the recruitment of NBS1 to DNA damage sites.

Signal transduction and targeted therapy

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Signal transduction and targeted therapy

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