Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis.

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作者： Dominik,Trzupek ^[1] ; Melanie,Dunstan ^[1] ; Antony J,Cutler ^[1] ; Mercede,Lee ^[1] ; Leila,Godfrey ^[1] ; Lorna,Jarvis ^[2] ; Daniel B,Rainbow ^[1] ; Dominik,Aschenbrenner ^[3] ; Joanne L,Jones ^[2] ; Holm H,Uhlig ^[3] ; Linda S,Wicker ^[1] ; John A,Todd ^[4] ; Ricardo C,Ferreira ^[5]

作者单位： Nuffield Department of Medicine, JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. ^[1] Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. ^[2] Translational Gastroenterology Unit and Department of Paediatrics, John Radcliffe Hospital, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. ^[3] Nuffield Department of Medicine, JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. john.todd@well.ox.ac.uk. ^[4] Nuffield Department of Medicine, JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. ricardo.ferreira@well.ox.ac.uk. ^[5]

关键词 AbSeq C-C chemokine receptor type 9 (CCR9)CD4+ T cells CD80 CD86 Immunophenotyping Multi-omics Regulatory T cells (Tregs)Single-cell RNA sequencing (scRNA-seq)