Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy.

导出 LinkOut

翻译打印收藏纠错

作者： Adria,Hasan ^[1] ; Ejazul,Haque ^[2] ; Rohil,Hameed ^[3] ; Paul N,Maier ^[4] ; Safia,Irfan ^[5] ; Mohd,Kamil ^[6] ; Aamir,Nazir ^[3] ; Snober S,Mir ^[7]

作者单位： Molecular Cell Biology Laboratory, Integral Information and Research Centre-4 (IIRC-4), Department of Bioengineering, Faculty of Engineering, Integral University, Kursi Road, Lucknow 226026, India. ^[1] Department of Biosciences, Faculty of Science, Integral University, Kursi Road, Lucknow 226026, India; Department of Immunology and Medical Genetics, University of Split, School of Medicine, Split, Croatia. ^[2] Laboratory of Functional Genomics and Molecular Toxicology, Division of Neuroscience and Ageing Biology, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India. ^[3] Molecular Cell Biology Laboratory, Integral Information and Research Centre-4 (IIRC-4), Department of Bioengineering, Faculty of Engineering, Integral University, Kursi Road, Lucknow 226026, India; University of Bonn, Regina-Pacis-Weg 3, 53113 Bonn, Germany. ^[4] Department of Biosciences, Faculty of Science, Integral University, Kursi Road, Lucknow 226026, India. ^[5] Department of Biosciences, Faculty of Science, Integral University, Kursi Road, Lucknow 226026, India; Department of Microbiology, Beykoz Institute of Life Sciences and Biotechnology (BILSAB), Bezmialem Vakif University, Istanbul, Turkey. ^[6] Molecular Cell Biology Laboratory, Integral Information and Research Centre-4 (IIRC-4), Department of Bioengineering, Faculty of Engineering, Integral University, Kursi Road, Lucknow 226026, India. Electronic address: smir@iul.ac.in. ^[7]

关键词 Apoptosis Autophagy ER stress Gedunin Hsp90

主题词抗肿瘤药, 植物(Antineoplastic Agents, Phytogenic);细胞凋亡(Apoptosis);自噬(Autophagy);剂量效应关系, 药物(Dose-Response Relationship, Drug);减量调节(Down-Regulation);HSP90热休克蛋白质类(HSP90 Heat-Shock Proteins);人类(Humans);柠檬苦素类(Limonins);肺肿瘤(Lung Neoplasms);膜电位, 线粒体(Membrane Potential, Mitochondrial);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);活性氧(Reactive Oxygen Species)

DOI 10.1016/j.lfs.2020.118000

PMID 32585246

发布时间 2021-12-04

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交

浏览6

Life sciences

2020年256卷

118000页

相似文献

中文期刊
外文期刊
学位论文
会议论文

检索历史清除

Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy.

Life sciences

相似文献

Life sciences

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy.

Life sciences

相似文献

Life sciences

相关期刊

检索历史清除