Novel β-carboline-based indole-4,7-quinone derivatives as NAD(P)H: Quinone-oxidoreductase-1 inhibitor with potent antitumor activities by inducing reactive oxygen species, apoptosis, and DNA damage.

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作者： Yibing,Guo ^[1] ; Liancheng,Xu ^[2] ; Changchun,Ling ^[1] ; Tao,Yang ^[2] ; Wenjie,Zheng ^[1] ; Jin,Lv ^[1] ; Qingsong,Guo ^[2] ; Bohua,Chen ^[1]

作者单位： Research Center of Clinical Medical, Affiliated Hospital of Nantong University, Nantong, China. ^[1] Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, China. ^[2]

关键词 antitumor activity apoptosis indole-4,7-quinone derivatives quinone oxidoreductase 1 reactive oxygen species β-Carboline

主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);咔啉类(Carbolines);DNA(DNA);DNA损伤(DNA Damage);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);HT29细胞(HT29 Cells);人类(Humans);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);NAD(P)H脱氢酶(醌)(NAD(P)H Dehydrogenase (Quinone));醌类(Quinones);活性氧(Reactive Oxygen Species);光谱分析(Spectrum Analysis);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1111/cbdd.13752

PMID 32592323

发布时间 2021-08-17

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Chemical biology & drug design

2020年96卷6期

1433-1446页

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Novel β-carboline-based indole-4,7-quinone derivatives as NAD(P)H: Quinone-oxidoreductase-1 inhibitor with potent antitumor activities by inducing reactive oxygen species, apoptosis, and DNA damage.

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Novel β-carboline-based indole-4,7-quinone derivatives as NAD(P)H: Quinone-oxidoreductase-1 inhibitor with potent antitumor activities by inducing reactive oxygen species, apoptosis, and DNA damage.

Chemical biology & drug design

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Chemical biology & drug design

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