Downregulation of low-density lipoprotein receptor class A domain-containing protein 4 (Ldlrad4) in the liver of rats treated with nongenotoxic hepatocarcinogen to induce transforming growth factor β signaling promoting cell proliferation and suppressing apoptosis in early hepatocarcinogenesis.

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作者： Yuko,Ito ^[1] ; Kota,Nakajima ^[2] ; Yasunori,Masubuchi ^[1] ; Satomi,Kikuchi ^[2] ; Hiromu,Okano ^[1] ; Fumiyo,Saito ^[2] ; Yumi,Akahori ^[1] ; Meilan,Jin ^[3] ; Toshinori,Yoshida ^[1] ; Makoto,Shibutani ^[3]

作者单位： Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan. ^[1] Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan. ^[2] Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan. ^[3] Chemicals Evaluation and Research Institute, Tokyo, Japan. ^[4] Department of Toxicology, Faculty of Veterinary Medicine, Okayama University of Science, Ehime, Japan. ^[5] Laboratory of Veterinary Pathology, College of Animal Science and Technology Veterinary Medicine, Southwest University, Chongqing, China. ^[6] Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, Tokyo, Japan. ^[7]

关键词 glutathione S-transferase placental form (GST-P)hepatocarcinogenesis low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4)nongenotoxic hepatocarcinogen rat transforming growth factor (TGF)-β signaling