首页> International journal of molecular sciences> Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism.

Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism.

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第一作者： Anne,Gläser

第一单位： Research Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.;Institute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany.

作者： Anne,Gläser ^[1] ; Franziska,Hammerl ^[2] ; Markus H,Gräler ^[3] ; Sina M,Coldewey ^[4] ; Christin,Völkner ^[5] ; Moritz J,Frech ^[6] ; Fan,Yang ^[5] ; Jiankai,Luo ^[6] ; Eric,Tönnies ^[7] ; Oliver,von Bohlen Und Halbach ^[7] ; Nicola,Brandt ^[2] ; Diana,Heimes ^[8] ; Anna-Maria,Neßlauer ^[8] ; Georg Christoph,Korenke ^[9] ; Marta,Owczarek-Lipska ^[10] ; John,Neidhardt ^[11] ; Arndt,Rolfs ^[12] ; Andreas,Wree ^[8] ; Martin,Witt ^[8] ; Anja Ursula,Bräuer ^[13]

作者单位： Research Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.;Institute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany. ^[1] Research Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany. ^[2] Department of Anaesthesiology and Intensive Care Medicine, Center for Sepsis Control and Care (CSCC), Center for Molecular Biomedicine (CMB), Jena University Hospital, 07745 Jena, Germany. ^[3] Department of Anaesthesiology and Intensive Care Medicine, Septomics Research Center, Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany. ^[4] Translational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. ^[5] Translational Neurodegeneration Section "Albrecht Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany.;Center for Transdisciplinary Neurosciences Rostock (CTNR), Rostock University Medical Center, University of Rostock, 18147 Rostock, Germany. ^[6] Institute of Anatomy and Cell Biology, University Medicine Greifswald, 17487 Greifswald, Germany. ^[7] Institute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany. ^[8] Department of Pediatrics, Klinikum Oldenburg, 26133 Oldenburg, Germany. ^[9] Human Genetics, School of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany.;Junior Research Group, Genetics of childhood brain malformations, School of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany. ^[10] Human Genetics, School of Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany.;Research Center for Neurosensory Science, Carl von Ossietzky University Oldenburg,26129 Oldenburg, Germany. ^[11] Centogene AG, D-18055 Rostock, Germany. ^[12] Research Group Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, 26129 Oldenburg, Germany.;Institute of Anatomy, Rostock University Medical Center, 18057 Rostock, Germany.;Research Center for Neurosensory Science, Carl von Ossietzky University Oldenburg,26129 Oldenburg, Germany. ^[13]

关键词 HPTLC Niemann–Pick disease type C1 S1P brain fibroblasts mass spectrometry qRT-PCR sphingolipids sphingosine-1-phosphate receptors white matter