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LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors.

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作者单位: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215. [1] Department of Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115. [2] Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105. [3] Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115. [4] Broad Institute, Cambridge, MA 02142. [5] Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115. [6] Department of Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; mlbulyk@genetics.med.harvard.edu young@wi.mit.edu george.daley@childrens.harvard.edu thomas_look@dfci.harvard.edu. [7] Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115. [8] Whitehead Institute for Biomedical Research, Cambridge, MA 02142; mlbulyk@genetics.med.harvard.edu young@wi.mit.edu george.daley@childrens.harvard.edu thomas_look@dfci.harvard.edu. [9] Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142. [10] Stem Cell Program, Division of Hematology/Oncology, Manton Center for Orphan Disease Research, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115; mlbulyk@genetics.med.harvard.edu young@wi.mit.edu george.daley@childrens.harvard.edu thomas_look@dfci.harvard.edu. [11] Department of Biological Chemistry and Molecular Pharmacology, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115. [12] Harvard Stem Cell Institute, Cambridge, MA 02138. [13] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215; mlbulyk@genetics.med.harvard.edu young@wi.mit.edu george.daley@childrens.harvard.edu thomas_look@dfci.harvard.edu. [14]
DOI 10.1073/pnas.1922692117
PMID 32601179
发布时间 2021-07-15
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Proceedings of the National Academy of Sciences of the United States of America

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