Macrophages confer resistance to BET inhibition in triple-negative breast cancer by upregulating IKBKE.

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第一作者： Jianghua,Qiao

第一单位： Department of Breast Disease, Henan Breast Cancer Center, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital. Zhengzhou 450008 China.

作者： Jianghua,Qiao ^[1] ; Yibing,Chen ^[2] ; Yanjun,Mi ^[3] ; Huan,Jin ^[4] ; Lina,Wang ^[1] ; Ting,Huang ^[4] ; Haolong,Li ^[4] ; Yucen,Song ^[2] ; Jun,Cao ^[2] ; Baoyan,Wu ^[4] ; Qiming,Wang ^[5] ; Zhengzhi,Zou ^[6]

作者单位： Department of Breast Disease, Henan Breast Cancer Center, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital. Zhengzhou 450008 China. ^[1] Genetic and Prenatal Diagnosis Center, Department of Gynecology and Obstetrics, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. ^[2] Department of Medical Oncology, Xiamen Key Laboratory of Antitumor Drug Transformation Research and Thoracic Tumor Diagnosis & Treatment, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen 361003, China. ^[3] MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China; Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China. ^[4] Department of Clinical Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital. Zhengzhou 450008, China. Electronic address: qimingwang1006@126.com. ^[5] MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China; Guangdong Provincial Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China. Electronic address: zouzhengzhi@m.scnu.edu.cn. ^[6]

关键词 BET inhibition IKBKE Macrophages STAT3 Triple-negative breast cancer