Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.-论文-万方医学网

作者： Karpagam,Srinivasan ^[1] ; Brad A,Friedman ^[2] ; Ainhoa,Etxeberria ^[1] ; Melanie A,Huntley ^[3] ; Marcel P,van der Brug ^[4] ; Oded,Foreman ^[5] ; Jonathan S,Paw ^[6] ; Zora,Modrusan ^[7] ; Thomas G,Beach ^[8] ; Geidy E,Serrano ^[8] ; David V,Hansen ^[9]

作者单位： Department of Neuroscience, Genentech, Inc., South San Francisco, CA, USA. ^[1] Department of Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, CA, USA. Electronic address: friedman.brad@gene.com. ^[2] Department of Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, CA, USA. ^[3] Department of Biomarker Discovery OMNI, Genentech, Inc., South San Francisco, CA, USA. ^[4] Department of Pathology, Genentech, Inc., South San Francisco, CA, USA. ^[5] Department of Immunology, Genentech, Inc., South San Francisco, CA, USA. ^[6] Department of Microchemistry, Proteomics and Lipidomics, Genentech, Inc., South San Francisco, CA, USA. ^[7] Banner Sun Health Research Institute, Sun City, AZ, USA. ^[8] Department of Neuroscience, Genentech, Inc., South San Francisco, CA, USA. Electronic address: dvhansen@chem.byu.edu. ^[9]

主题词老年人(Aged);老年人, 80以上(Aged, 80 and over);阿尔茨海默病(Alzheimer Disease);动物(Animals);数据库, 遗传学(Databases, Genetic);女(雌)性(Female);额叶(Frontal Lobe);冷冻切片(Frozen Sections);基因表达谱(Gene Expression Profiling);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);男(雄)性(Male);小鼠(Mice);小神经胶质细胞(Microglia);单核细胞(Monocytes);多发性硬化(Multiple Sclerosis);表型(Phenotype);结果可重复性(Reproducibility of Results);危险因素(Risk Factors);颞叶(Temporal Lobe);转录激活(Transcriptional Activation)

DOI 10.1016/j.celrep.2020.107843

PMID 32610143

发布时间 2024-03-29

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Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.

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Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.

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