Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ<sub>42</sub> in triggering receptor expressed on myeloid cells 2 loss-of-function murine models.-论文-万方医学网

作者： Zhouyi,Rong ^[1] ; Baoying,Cheng ^[1] ; Li,Zhong ^[1] ; Xiaowen,Ye ^[1] ; Xin,Li ^[1] ; Lin,Jia ^[1] ; Yanfang,Li ^[1] ; Francis,Shue ^[2] ; Na,Wang ^[3] ; Yiyun,Cheng ^[1] ; Xiaohua,Huang ^[1] ; Chia-Chen,Liu ^[4] ; John D,Fryer ^[3] ; Xin,Wang ^[3] ; Yun-Wu,Zhang ^[1] ; Honghua,Zheng ^[5]

作者单位： Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen, China. ^[1] Shenzhen Research Institute, Xiamen University, Shenzhen, China. ^[2] Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. ^[3] Basic Medical Sciences, School of Medicine, Xiamen University, Xiamen, China. ^[4] State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen, China. ^[5]

主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);脑(Brain);细胞运动(Cell Movement);细胞, 培养的(Cells, Cultured);疾病模型, 动物(Disease Models, Animal);黏着斑激酶1(Focal Adhesion Kinase 1);GTP磷酸水解酶类(GTP Phosphohydrolases);男(雄)性(Male);膜糖蛋白类(Membrane Glycoproteins);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);小神经胶质细胞(Microglia);髓系细胞(Myeloid Cells);神经肽类(Neuropeptides);肽碎片(Peptide Fragments);信号传导(Signal Transduction);cdc42 GTP结合蛋白质(cdc42 GTP-Binding Protein);rac1 GTP结合蛋白质(rac1 GTP-Binding Protein)

DOI 10.1096/fj.202000550RR

PMID 32613609

发布时间 2021-02-25

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Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ<sub>42</sub> in triggering receptor expressed on myeloid cells 2 loss-of-function murine models.

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Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ<sub>42</sub> in triggering receptor expressed on myeloid cells 2 loss-of-function murine models.

FASEB journal

相似文献

FASEB journal

相关期刊

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