An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth.

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作者： Vania,Vidimar ^[1] ; Greg L,Beilhartz ^[2] ; Minyoung,Park ^[2] ; Marco,Biancucci ^[3] ; Matthew B,Kieffer ^[1] ; David R,Gius ^[1] ; Roman A,Melnyk ^[4] ; Karla J F,Satchell ^[5]

作者单位： Department of Microbiology and Immunology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611. ^[1] Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada. ^[2] Department of Biochemistry, University of Toronto, Toronto, Canada M5S 1A8. ^[3] Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611. ^[4] Robert H. Lurie Comprehensive Cancer Research Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611. ^[5] Program in Molecular Medicine, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; k-satchell@northwestern.edu roman.melnyk@sickkids.ca. ^[6] Department of Microbiology and Immunology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611; k-satchell@northwestern.edu roman.melnyk@sickkids.ca. ^[7]

关键词 RAS RRSP cancer recombinant toxins xenograft