Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway.

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第一作者： Mingzhe,Li

第一单位： Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China.

作者： Mingzhe,Li ^[1] ; Jimin,Wu ^[1] ; Guomin,Hu ^[1] ; Yao,Song ^[1] ; Jing,Shen ^[1] ; Junzhou,Xin ^[1] ; Zijian,Li ^[1] ; Wei,Liu ^[2] ; Erdan,Dong ^[3] ; Ming,Xu ^[1] ; Youyi,Zhang ^[4] ; Han,Xiao ^[5]

作者单位： Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China. ^[1] Division of Cardiovascular Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, M13 9PT, UK. ^[2] Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China.;Institute of Cardiovascular Sciences, Health Science Center, Peking University, Beijing, 100191, China. ^[3] Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China. zhangyy@bjmu.edu.cn. ^[4] Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China. xiaohan@bjmu.edu.cn. ^[5]

关键词 POU2F1 cardiac fibrosis fibroblast differentiation matrix stiffness transcription factor

主题词动物(Animals);结合部位(Binding Sites);细胞分化(Cell Differentiation);细胞, 培养的(Cells, Cultured);细胞外基质(Extracellular Matrix);成纤维细胞(Fibroblasts);纤维化(Fibrosis);基因表达谱(Gene Expression Profiling);基因表达调控(Gene Expression Regulation);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);心肌(Myocardium);肌成纤维细胞(Myofibroblasts);八聚体转录因子1(Octamer Transcription Factor-1);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);受体, 白细胞介素1Ⅱ型(Receptors, Interleukin-1 Type II);信号传导(Signal Transduction);小鼠(Mice)

DOI 10.1007/s11427-019-1747-y

PMID 32617828

发布时间 2024-02-26

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Science China. Life sciences

2021年64卷2期

242-254页

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Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway.

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Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway.

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