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首页> Prostaglandins, leukotrienes, and essential fatty acids> Evaluation of cyclooxygenase oxylipins as potential biomarker for obesity-associated adipose tissue inflammation and type 2 diabetes using targeted multiple reaction monitoring mass spectrometry.

Evaluation of cyclooxygenase oxylipins as potential biomarker for obesity-associated adipose tissue inflammation and type 2 diabetes using targeted multiple reaction monitoring mass spectrometry.

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作者： Roel,Tans ^[1] ; Rieke,Bande ^[1] ; Arno,van Rooij ^[1] ; Billy J,Molloy ^[2] ; Rinke,Stienstra ^[3] ; Cees J,Tack ^[3] ; Ron A,Wevers ^[1] ; Hans J C T,Wessels ^[1] ; Jolein,Gloerich ^[1] ; Alain J,van Gool ^[4]

作者单位： Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands. ^[1] Waters Corporation, Wilmslow, United Kingdom. ^[2] Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands. ^[3] Translational Metabolic Laboratory, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands. Electronic address: Alain.vanGool@radboudumc.nl. ^[4]

关键词 Assay developmentl Biomarker validation Mass spectrometry Oxylipins Type 2 diabetes

主题词脂肪组织(Adipose Tissue);色谱法, 高压液相(Chromatography, High Pressure Liquid);环氧化酶2(Cyclooxygenase 2);糖尿病, 2型(Diabetes Mellitus, Type 2);人类(Humans);质谱分析法(Mass Spectrometry);肥胖症(Obesity);氧化脂类(Oxylipins);固相萃取(Solid Phase Extraction);工作流(Workflow)

DOI 10.1016/j.plefa.2020.102157

PMID 32629236

发布时间 2020-11-04

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