Human translatability of the GAN diet-induced obese mouse model of non-alcoholic steatohepatitis.

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第一作者： Henrik H,Hansen

第一单位： Gubra, DK-2970, Hørsholm, Denmark. hbh@gubra.dk.

作者： Henrik H,Hansen ^[1] ; Helene M,Ægidius ^[2] ; Denise,Oró ^[2] ; Simon S,Evers ^[2] ; Sara,Heebøll ^[3] ; Peter Lykke,Eriksen ^[3] ; Karen Louise,Thomsen ^[3] ; Anja,Bengtsson ^[2] ; Sanne S,Veidal ^[2] ; Michel,Feigh ^[2] ; Malte P,Suppli ^[4] ; Filip K,Knop ^[4] ; Henning,Grønbæk ^[5] ; Diego,Miranda ^[6] ; James L,Trevaskis ^[3] ; Niels,Vrang ^[7] ; Jacob,Jelsing ^[7] ; Kristoffer T G,Rigbolt ^[2]

作者单位： Gubra, DK-2970, Hørsholm, Denmark. hbh@gubra.dk. ^[1] Gubra, DK-2970, Hørsholm, Denmark. ^[2] Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark. ^[3] Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. ^[4] Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. ^[5] Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. ^[6] Gilead Sciences, Foster City, CA, USA. ^[7]

关键词 Diet-induced obesity Glucose tolerance Histomorphometry Histopathology Liver transcriptome Mouse model Non-alcoholic steatohepatitis Translatability