Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation.

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第一作者： Zhicheng,Su

第一单位： Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China.

作者： Zhicheng,Su ^[1] ; Tingyuan,Yang ^[1] ; Jie,Wang ^[1] ; Mengzhen,Lai ^[2] ; Linjiang,Tong ^[3] ; Gulinuer,Wumaier ^[4] ; Zhuo,Chen ^[5] ; Shengqing,Li ^[4] ; Honglin,Li ^[1] ; Hua,Xie ^[6] ; Zhenjiang,Zhao ^[7]

作者单位： Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China. ^[1] Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmacy, Fudan University, Shanghai 201203, China. ^[2] Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[3] Department of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, China. ^[4] Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China. Electronic address: chenzhuo@ecust.edu.cn. ^[5] Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: hxie@simm.ac.cn. ^[6] Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, Shanghai 200237, China. Electronic address: zhjzhao@ecust.edu.cn. ^[7]

关键词 C797S EGFR NSCLC