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Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.

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第一作者： Hersh K,Bhargava

第一单位： Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.;California Institute for Quantitative Biosciences, University of California, Berkeley CA 94720.

作者： Hersh K,Bhargava ^[1] ; Keisuke,Tabata ^[2] ; Jordan M,Byck ^[1] ; Maho,Hamasaki ^[3] ; Daniel P,Farrell ^[4] ; Ivan,Anishchenko ^[4] ; Frank,DiMaio ^[4] ; Young Jun,Im ^[5] ; Tamotsu,Yoshimori ^[6] ; James H,Hurley ^[7]

作者单位： Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.;California Institute for Quantitative Biosciences, University of California, Berkeley CA 94720. ^[1] Department of Genetics, Graduate School of Medicine, Osaka University, 565-0871 Osaka, Japan. ^[2] Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, 565-0871 Osaka, Japan. ^[3] Department of Biochemistry, University of Washington, Seattle, WA 98195.;Institute for Protein Design, University of Washington, Seattle, WA 98195. ^[4] College of Pharmacy, Chonnam National University, Gwangju, 61186, Republic of Korea. ^[5] Department of Genetics, Graduate School of Medicine, Osaka University, 565-0871 Osaka, Japan.;Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, 565-0871 Osaka, Japan. ^[6] Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720; jimhurley@berkeley.edu.;California Institute for Quantitative Biosciences, University of California, Berkeley CA 94720.;Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720. ^[7]

关键词 Rab GTPase autophagy crystal structure

医学主题词自噬(Autophagy);结晶学, X线(Crystallography, X-Ray);人类(Humans);模型, 分子(Models, Molecular);蛋白质结合(Protein Binding);rab GTP结合蛋白质类(rab GTP-Binding Proteins)

DOI 10.1073/pnas.2008030117

PMID 32632011

发布时间 2021-12-04

基金项目

P30 GM124169/GM/NIGMS NIH HHS/United States R01 GM111730/GM/NIGMS NIH HHS/United States R01 GM124149/GM/NIGMS NIH HHS/United States

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