首页> Molecular psychiatry> MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis.

MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis.

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第一作者： Jiqing,Cao

第一单位： James J Peters VA Medical Center, Research & Development, Bronx, NY, 10468, USA.;Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

作者： Jiqing,Cao ^[1] ; Min,Huang ^[1] ; Lei,Guo ^[2] ; Li,Zhu ^[1] ; Jianwei,Hou ^[1] ; Larry,Zhang ^[1] ; Adriana,Pero ^[1] ; Sabrina,Ng ^[3] ; Farida,El Gaamouch ^[4] ; Gregory,Elder ^[1] ; Mary,Sano ^[5] ; Alison,Goate ^[6] ; Julia,Tcw ^[6] ; Vahram,Haroutunian ^[7] ; Bin,Zhang ^[2] ; Dongming,Cai ^[8]

作者单位： James J Peters VA Medical Center, Research & Development, Bronx, NY, 10468, USA.;Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ^[1] Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.;Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ^[2] James J Peters VA Medical Center, Research & Development, Bronx, NY, 10468, USA.;Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.;Cornell University, Ithaca, NY, 14850, USA. ^[3] Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ^[4] James J Peters VA Medical Center, Research & Development, Bronx, NY, 10468, USA.;Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.;Alzheimer Disease Rsearch Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ^[5] Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.;Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ^[6] Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.;Alzheimer Disease Rsearch Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.;Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.;James J Peters VA Medical Center, MIRECC, Bronx, NY, 10468, USA. ^[7] James J Peters VA Medical Center, Research & Development, Bronx, NY, 10468, USA. dongming.cai@mssm.edu.;Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. dongming.cai@mssm.edu.;Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. dongming.cai@mssm.edu.;Alzheimer Disease Rsearch Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. dongming.cai@mssm.edu.;Ronald M. Loeb Center for Alzheimer's disease, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. dongming.cai@mssm.edu. ^[8]

医学主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);载脂蛋白E4(Apolipoprotein E4);认知(Cognition);人类(Humans);溶酶体(Lysosomes);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);微RNAs(MicroRNAs)

DOI 10.1038/s41380-020-0824-3

PMID 32632205

发布时间 2025-01-12

基金项目

RF1 AG057440/AG/NIA NIH HHS/United States RF1 AG054014/AG/NIA NIH HHS/United States U01 AG052411/AG/NIA NIH HHS/United States I01 RX002290/RX/RRD VA/United States K01 AG062683/AG/NIA NIH HHS/United States RF1 AG059319/AG/NIA NIH HHS/United States I01 RX002660/RX/RRD VA/United States U01 AG058635/AG/NIA NIH HHS/United States RF1 AG048923/AG/NIA NIH HHS/United States P30 AG066514/AG/NIA NIH HHS/United States R01 AG048923/AG/NIA NIH HHS/United States U01 AG046170/AG/NIA NIH HHS/United States I01 BX003380/BX/BLRD VA/United States I01 CX000619/CX/CSRD VA/United States R56 AG058655/AG/NIA NIH HHS/United States

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