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A Single-Cell Transcriptomics CRISPR-Activation Screen Identifies Epigenetic Regulators of the Zygotic Genome Activation Program.

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第一作者： Celia,Alda-Catalinas

第一单位： Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

作者： Celia,Alda-Catalinas ^[1] ; Danila,Bredikhin ^[2] ; Irene,Hernando-Herraez ^[3] ; Fátima,Santos ^[3] ; Oana,Kubinyecz ^[3] ; Mélanie A,Eckersley-Maslin ^[4] ; Oliver,Stegle ^[5] ; Wolf,Reik ^[6]

作者单位： Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. ^[1] European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg 69117, Germany. ^[2] Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK. ^[3] Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK. Electronic address: eckersleym@babraham.ac.uk. ^[4] European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg 69117, Germany; Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SA, UK; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. Electronic address: oliver.stegle@embl.de. ^[5] Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK; Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK; Centre for Trophoblast Research University of Cambridge, Cambridge CB2 3EG, UK. Electronic address: wolf.reik@babraham.ac.uk. ^[6]

关键词 CRISPRa Dppa2 MOFA Patz1 Smarca5 ZGA scRNA-seq screen single cell zygotic genome activation

医学主题词后成说, 遗传(Epigenesis, Genetic);基因组(Genome);人类(Humans);合子(Zygote)

DOI 10.1016/j.cels.2020.06.004

PMID 32634384

发布时间 2025-05-30

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