Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol.-论文-万方医学网

作者： Yue,Fu ^[1] ; David,Estoppey ^[2] ; Silvio,Roggo ^[2] ; Dominik,Pistorius ^[2] ; Florian,Fuchs ^[2] ; Christian,Studer ^[2] ; Ashraf S,Ibrahim ^[3] ; Thomas,Aust ^[2] ; Frederic,Grandjean ^[2] ; Manuel,Mihalic ^[2] ; Klaus,Memmert ^[2] ; Vivian,Prindle ^[1] ; Etienne,Richard ^[2] ; Ralph,Riedl ^[2] ; Sven,Schuierer ^[2] ; Eric,Weber ^[2] ; Jürg,Hunziker ^[2] ; Frank,Petersen ^[2] ; Jianshi,Tao ^[4] ; Dominic,Hoepfner ^[5]

作者单位： Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA, 92121, USA. ^[1] Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056, Basel, Switzerland. ^[2] The Lundquist Institute for Biomedical Innovations at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, 90502, USA.;David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. ^[3] Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA, 92121, USA. jtao@gnf.org. ^[4] Novartis Institutes for BioMedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, CH-4056, Basel, Switzerland. dominic.hoepfner@novartis.com. ^[5]

主题词动物(Animals);抗真菌药(Antifungal Agents);细胞增殖(Cell Proliferation);疾病模型, 动物(Disease Models, Animal);发酵(Fermentation);基因, 报告(Genes, Reporter);糖基磷脂酰肌醇类(Glycosylphosphatidylinositols);糖基转移酶类(Glycosyltransferases);HCT116细胞(HCT116 Cells);Hep G2细胞(Hep G2 Cells);人类(Humans);氢离子浓度(Hydrogen-Ion Concentration);半数抑制浓度(Inhibitory Concentration 50);K562细胞(K562 Cells);肺(Lung);男(雄)性(Male);小鼠(Mice);小鼠, 近交ICR(Mice, Inbred ICR);毛霉菌目(Mucorales);多基因族(Multigene Family);根霉菌属(Rhizopus);酿酒酵母菌(Saccharomyces cerevisiae);酿酒酵母蛋白质类(Saccharomyces cerevisiae Proteins)

DOI 10.1038/s41467-020-17221-5

PMID 32636417

发布时间 2024-09-22

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Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol.

Nature communications

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Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol.

Nature communications

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Nature communications

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