RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma.
作者:
关键词
4EBP-1, E binding protein-1AKTAKT, protein kinase B (PKB)ESCC, esophageal squamous cell carcinomaEsophageal squamous cell carcinomaFDA, U.S. Food and Drug AdministrationH&E staining, hematoxylin and eosin stainingIC50, half maximal inhibitory concentrationPI3K, phosphatidylinositol 3 kinaseRAD001RICTORRICTOR, rapamycin-insensitive companion of mTORTNM, tumor-node-metastasisTUNEL, terminal deoxynucleotidyl transferase dUTP nick end labelingmTOR, mammalian target of rapamycinmTORC1, mTOR complex 1mTORC2, mTOR complex 2p70S6K, p70 ribosomal S6 kinase-1pp242rapalogs, rapamycin and its analogs
DOI
10.1016/j.apsb.2020.01.010
PMID
32642408
发布时间
2020-09-28
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Acta pharmaceutica Sinica. B
2020年10卷6期
1004-1019页
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