In Situ Fucosylation of the Wnt Co-receptor LRP6 Increases Its Endocytosis and Reduces Wnt/β-Catenin Signaling.

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第一作者： Senlian,Hong

第一单位： Department of Molecular Medicine, The Scripps Research Institute, La Jolla CA 92037, USA.

作者： Senlian,Hong ^[1] ; Lei,Feng ^[2] ; Yi,Yang ^[1] ; Hao,Jiang ^[3] ; Xiaomeng,Hou ^[1] ; Peng,Guo ^[4] ; Florence L,Marlow ^[5] ; Pamela,Stanley ^[6] ; Peng,Wu ^[7]

作者单位： Department of Molecular Medicine, The Scripps Research Institute, La Jolla CA 92037, USA. ^[1] Department of Biochemistry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA. ^[2] Department of Biochemistry, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA; The School of Medicine and Pharmacy, Ocean University of China 5 Yushan Road, Qingdao 266003, China. ^[3] Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA. ^[4] Department of Cell Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[5] Department of Cell Biology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA. ^[6] Department of Molecular Medicine, The Scripps Research Institute, La Jolla CA 92037, USA. Electronic address: pengwu@scripps.edu. ^[7]

关键词 (1–3)-fucosylation LRP6 Wnt signaling/β-catenin signaling endocytosis

主题词动物(Animals);CHO细胞(CHO Cells);细胞系(Cell Line);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);胚胎, 非哺乳动物(Embryo, Nonmammalian);胞吞作用(Endocytosis);岩藻糖(Fucose);糖基化(Glycosylation);人类(Humans);膜微区(Membrane Microdomains);单糖转运蛋白质类(Monosaccharide Transport Proteins);Wnt蛋白质类(Wnt Proteins);斑马鱼(Zebrafish);β连环素(beta Catenin)

DOI 10.1016/j.chembiol.2020.06.015

PMID 32649905

发布时间 2021-09-18

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Cell chemical biology

2020年27卷9期

1140-1150.e4页

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In Situ Fucosylation of the Wnt Co-receptor LRP6 Increases Its Endocytosis and Reduces Wnt/β-Catenin Signaling.

Cell chemical biology

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In Situ Fucosylation of the Wnt Co-receptor LRP6 Increases Its Endocytosis and Reduces Wnt/β-Catenin Signaling.

Cell chemical biology

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Cell chemical biology

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