The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients.

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第一作者： Zongwei,Guo

第一单位： School of Bioengineering, Dalian University of Technology, Dalian, Liaoning, China.

作者： Zongwei,Guo ^[1] ; Ting,Song ^[2] ; Ziqian,Wang ^[3] ; Donghai,Lin ^[4] ; Keke,Cao ^[1] ; Peng,Liu ^[1] ; Yingang,Feng ^[5] ; Xiaodong,Zhang ^[3] ; Peiran,Wang ^[3] ; Fangkui,Yin ^[3] ; Jian,Dai ^[3] ; Sheng,Zhou ^[3] ; Zhichao,Zhang ^[6]

作者单位： School of Bioengineering, Dalian University of Technology, Dalian, Liaoning, China. ^[1] State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China. Electronic address: songting@dlut.edu.cn. ^[2] State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China. ^[3] The Key Laboratory for Chemical Biology of Fujian ProvinceMOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian ProvinceMOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Xiamen, Fujian, China. ^[4] Shandong Key Laboratory of Synthetic Biology, CAS Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, Shandong, China. ^[5] State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian, Liaoning, China. Electronic address: zczhang@dlut.edu.cn. ^[6]

关键词 70-kilodalton heat shock protein AKT PKB B-cell lymphoma 2 (Bcl-2) family BH3 receptor Bim Hsp70 Raf kinase allosteric regulation apoptosis chaperone co-chaperone heat shock protein (HSP)