Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice.

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作者： Yuto,Nakamura ^[1] ; Shunbun,Kita ^[2] ; Yoshimitsu,Tanaka ^[1] ; Shiro,Fukuda ^[1] ; Yoshinari,Obata ^[1] ; Tomonori,Okita ^[1] ; Hiroyuki,Nishida ^[3] ; Yuki,Takahashi ^[4] ; Yusuke,Kawachi ^[1] ; Yuri,Tsugawa-Shimizu ^[1] ; Yuya,Fujishima ^[1] ; Hitoshi,Nishizawa ^[1] ; Yoshinobu,Takakura ^[4] ; Shigeru,Miyagawa ^[5] ; Yoshiki,Sawa ^[6] ; Norikazu,Maeda ^[7] ; Iichiro,Shimomura ^[1]

作者单位： Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan. ^[1] Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan; Department of Adipose Management, Graduate School of Medicine, Osaka University, Osaka, Japan. Electronic address: shunkita@endmet.med.osaka-u.ac.jp. ^[2] ROHTO Pharmaceutical Co., Ltd. Osaka, Japan; Department of Advanced Stem Cell Therapy, Graduate School of Medicine, Osaka University, Osaka, Japan. ^[3] Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan. ^[4] Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan. ^[5] Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan; Medical Center for Translational Research, Osaka University Hospital, Osaka, Japan. ^[6] Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan; Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Osaka, Japan. ^[7]

关键词 MSC T-cadherin TAC model adiponectin exosome extracellular vesicle heart failure mesenchymal stem/stromal cell