Conjugation of arginylglycylaspartic acid to human serum albumin decreases the tumor-targeting effect of albumin by hindering its secreted protein acidic and rich in cysteine-mediated accumulation in tumors.

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第一作者： Cho Rong,Park

第一单位： Department of Nuclear Medicine, Seoul National University College of Medicine Seoul, Korea.

作者： Cho Rong,Park ^[1] ; Myung Geun,Song ^[2] ; Ji-Yong,Park ^[3] ; Hyewon,Youn ^[1] ; June-Key,Chung ^[4] ; Jae Min,Jeong ^[1] ; Yun-Sang,Lee ^[3] ; Gi Jeong,Cheon ^[1] ; Keon Wook,Kang ^[2]

作者单位： Department of Nuclear Medicine, Seoul National University College of Medicine Seoul, Korea. ^[1] Cancer Research Institute, Seoul National University College of Medicine Seoul, Korea. ^[2] Department of Biomedical Sciences, Seoul National University Graduate School Seoul, Korea. ^[3] Biomedical Research Institute, Seoul National University Hospital Seoul, Korea. ^[4] Cancer Imaging Center, Seoul National University Hospital Seoul, Korea. ^[5] Tumor Microenvironment Global Core Research Center, Seoul National University Seoul, Korea. ^[6] Institute of Radiation Medicine, Medical Research Center, Seoul National University College of Medicine Seoul, Korea. ^[7] National Cancer Center Goyang, Korea. ^[8] Tumor Biology Program, Seoul National University College of Medicine Seoul, Korea. ^[9]

关键词 EPR effect Human serum albumin RGD SPARC tumor targeting

PMID 32655786

发布时间 2020-09-28

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