Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System.

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作者： Luke M,Simpson ^[1] ; Thomas J,Macartney ^[1] ; Alice,Nardin ^[1] ; Luke J,Fulcher ^[2] ; Sascha,Röth ^[1] ; Andrea,Testa ^[3] ; Chiara,Maniaci ^[4] ; Alessio,Ciulli ^[5] ; Ian G,Ganley ^[1] ; Gopal P,Sapkota ^[6]

作者单位： Medical Research Council (MRC) Protein Phosphorylation & Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. ^[1] Medical Research Council (MRC) Protein Phosphorylation & Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. ^[2] Division of Biological Chemistry & Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK; Amphista Therapeutics Ltd, Bo'Ness Road, Newhouse ML1 5UH, UK. ^[3] Division of Biological Chemistry & Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK; School of Natural & Environmental Sciences, Chemistry Bedson Building, Kings Road, Newcastle University, Newcastle Upon Tyne NE1 7RU, UK. ^[4] Division of Biological Chemistry & Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. ^[5] Medical Research Council (MRC) Protein Phosphorylation & Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Electronic address: g.sapkota@dundee.ac.uk. ^[6]

关键词 AdPROM FAM83D HaloPROTAC PROTAC RAS SGK3 ULK1 monobody nanobody targeted proteolysis

主题词亲和力标记物(Affinity Labels);细胞周期蛋白质类(Cell Cycle Proteins);细胞系(Cell Line);基因敲入技术(Gene Knock-In Techniques);绿色荧光蛋白质类(Green Fluorescent Proteins);人类(Humans);微管相关蛋白质类(Microtubule-Associated Proteins);肽类(Peptides);重组融合蛋白质类(Recombinant Fusion Proteins);单链抗体(Single-Chain Antibodies);泛素化(Ubiquitination);ras蛋白质类(ras Proteins)

DOI 10.1016/j.chembiol.2020.06.013

PMID 32668203

发布时间 2024-03-29

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Cell chemical biology

2020年27卷9期

1164-1180.e5页

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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System.

Cell chemical biology

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Cell chemical biology

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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System.

Cell chemical biology

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Cell chemical biology

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