Investigation of the safety and feasibility of AAV1/SERCA2a gene transfer in patients with chronic heart failure supported with a left ventricular assist device - the SERCA-LVAD TRIAL.

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作者： A R,Lyon ^[1] ; D,Babalis ^[2] ; A C,Morley-Smith ^[3] ; M,Hedger ^[4] ; A,Suarez Barrientos ^[5] ; G,Foldes ^[5] ; L S,Couch ^[5] ; R A,Chowdhury ^[4] ; K N,Tzortzis ^[4] ; N S,Peters ^[4] ; E A,Rog-Zielinska ^[4] ; H-Y,Yang ^[4] ; S,Welch ^[4] ; C T,Bowles ^[6] ; S,Rahman Haley ^[4] ; A R,Bell ^[4] ; A,Rice ^[5] ; T,Sasikaran ^[5] ; N A,Johnson ^[5] ; E,Falaschetti ^[7] ; J,Parameshwar ^[7] ; C,Lewis ^[3] ; S,Tsui ^[3] ; A,Simon ^[3] ; J,Pepper ^[8] ; J J,Rudy ^[8] ; K M,Zsebo ^[8] ; K T,Macleod ^[4] ; C M,Terracciano ^[5] ; R J,Hajjar ^[4] ; N,Banner ^[5] ; S E,Harding ^[9]

作者单位： National Heart and Lung Institute, Imperial College London, London, UK. a.lyon@imperial.ac.uk. ^[1] NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield Hospitals NHS Trust, London, UK. a.lyon@imperial.ac.uk. ^[2] Imperial Clinical Trials Unit (ICTU), School of Public Health, Imperial College London, London, UK. ^[3] National Heart and Lung Institute, Imperial College London, London, UK. ^[4] NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield Hospitals NHS Trust, London, UK. ^[5] Institute for Experimental Cardiovascular Medicine, University Heart Center, Medical Center, University of Freiburg, Freiburg, Germany. ^[6] Department of Histopathology, Royal Brompton and Harefield Hospitals NHS Trust, Freiburg, Germany. ^[7] Royal Papworth Hospital NHS Trust, Cambridge, UK. ^[8] Celladon Corporation, San Diego, CA, USA. ^[9] Phospholamban Foundation, Amsterdam, Netherlands. ^[10]