Scavenging of Dickkopf-1 by macromer-based biomaterials covalently decorated with sulfated hyaluronan displays pro-osteogenic effects.

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第一作者： M,Gronbach

第一单位： University of Leipzig, Medical Faculty, Pharmaceutical Technology, Eilenburger Str. 15A, 04317 Leipzig, Germany.

作者： M,Gronbach ^[1] ; F,Mitrach ^[1] ; V,Lidzba ^[1] ; B,Müller ^[1] ; S,Möller ^[2] ; S,Rother ^[3] ; J,Salbach-Hirsch ^[4] ; L C,Hofbauer ^[5] ; M,Schnabelrauch ^[2] ; V,Hintze ^[3] ; M C,Hacker ^[1] ; M,Schulz-Siegmund ^[6]

作者单位： University of Leipzig, Medical Faculty, Pharmaceutical Technology, Eilenburger Str. 15A, 04317 Leipzig, Germany. ^[1] INNOVENT e.V., Biomaterials Department, Pruessingstraße 27B, Jena, Germany. ^[2] Max Bergmann Center of Biomaterials, Technische Universität Dresden, Budapester Str. 27, 01062 Dresden, Germany. ^[3] Department of Medicine III, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany. ^[4] Department of Medicine III, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany; Center for Healthy Aging, Technische Universität Dresden, Fetscherstr. 74, 01307 Dresden, Germany. ^[5] University of Leipzig, Medical Faculty, Pharmaceutical Technology, Eilenburger Str. 15A, 04317 Leipzig, Germany. Electronic address: schulz@uni-leipzig.de. ^[6]

关键词 Biodegradable polymer Bone regeneration Dickkopf-1 Hyaluronan Scavenging Surface modification Tissue engineering Wnt-signaling

主题词生物相容性材料(Biocompatible Materials);细胞分化(Cell Differentiation);透明质酸(Hyaluronic Acid);骨生成(Osteogenesis);硫酸盐类(Sulfates)

DOI 10.1016/j.actbio.2020.07.017

PMID 32673749

发布时间 2021-05-14

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