Mthfd2 Modulates Mitochondrial Function and DNA Repair to Maintain the Pluripotency of Mouse Stem Cells.-论文-万方医学网

第一作者： Liang,Yue

第一单位： State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China; Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100083, China.

作者： Liang,Yue ^[1] ; Yangli,Pei ^[2] ; Liang,Zhong ^[3] ; Henry,Yang ^[4] ; Yanliang,Wang ^[5] ; Wei,Zhang ^[5] ; Naixin,Chen ^[5] ; Qianqian,Zhu ^[5] ; Jie,Gao ^[5] ; Minglei,Zhi ^[5] ; Bingqiang,Wen ^[5] ; Shaopeng,Zhang ^[5] ; Jinzhu,Xiang ^[5] ; Qingqing,Wei ^[5] ; Hui,Liang ^[5] ; Suying,Cao ^[6] ; Huiqiang,Lou ^[5] ; Zhongzhou,Chen ^[5] ; Jianyong,Han ^[7]

作者单位： State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China; Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100083, China. ^[1] State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China; School of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China. ^[2] State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China; Hebei Provincial Key Laboratory of Basic Medicine for Diabetes, The Shijiazhuang Second Hospital, Shijiazhuang, Hebei 050051, China. ^[3] Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore. ^[4] State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China. ^[5] Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China. ^[6] State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China; Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100083, China. Electronic address: hanjy@cau.edu.cn. ^[7]

主题词氨基水解酶类(Aminohydrolases);动物(Animals);CDC2蛋白激酶(CDC2 Protein Kinase);细胞核(Cell Nucleus);DNA损伤(DNA Damage);DNA修复(DNA Repair);DNA修复酶类(DNA Repair Enzymes);电子传递复合物Ⅲ(Electron Transport Complex III);脱氧核糖核酸外切酶类(Exodeoxyribonucleases);基因表达调控(Gene Expression Regulation);葡萄糖(Glucose);糖酵解(Glycolysis);诱导多能干细胞(Induced Pluripotent Stem Cells);甲烷四氢叶酸环水解酶(Methenyltetrahydrofolate Cyclohydrolase);亚甲基四氢叶酸脱氢酶(NADP)(Methylenetetrahydrofolate Dehydrogenase (NADP));小鼠(Mice);线粒体(Mitochondria);多酶复合物(Multienzyme Complexes);氧化磷酸化(Oxidative Phosphorylation);磷酰化(Phosphorylation);蛋白质结合(Protein Binding)

DOI 10.1016/j.stemcr.2020.06.018

PMID 32679066

发布时间 2021-06-02

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Mthfd2 Modulates Mitochondrial Function and DNA Repair to Maintain the Pluripotency of Mouse Stem Cells.

Stem cell reports

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Stem cell reports

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Mthfd2 Modulates Mitochondrial Function and DNA Repair to Maintain the Pluripotency of Mouse Stem Cells.

Stem cell reports

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Stem cell reports

相关期刊

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