CRISPR-Cas12a with an oAd Induces Precise and Cancer-Specific Genomic Reprogramming of EGFR and Efficient Tumor Regression.

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作者： A-Rum,Yoon ^[1] ; Bo-Kyeong,Jung ^[2] ; Eunyoung,Choi ^[3] ; Eugene,Chung ^[4] ; JinWoo,Hong ^[5] ; Jin-Soo,Kim ^[6] ; Taeyoung,Koo ^[7] ; Chae-Ok,Yun ^[8]

作者单位： Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea; Institute of Nano Science and Technology (INST), Hanyang University, Seoul 04763, Republic of Korea. ^[1] Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea. ^[2] Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea. ^[3] Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea. ^[4] Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea; GeneMedicine Co., Ltd., Seoul 04763, Republic of Korea. ^[5] Institute for Basic Science (IBS), Daejeon 34126, Republic of Korea. Electronic address: jskim01@snu.ac.kr. ^[6] Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: taeyoungkoo@khu.ac.kr. ^[7] Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea; Institute of Nano Science and Technology (INST), Hanyang University, Seoul 04763, Republic of Korea; GeneMedicine Co., Ltd., Seoul 04763, Republic of Korea. Electronic address: chaeok@hanyang.ac.kr. ^[8]

关键词 CRISPR Cas12a Cpf1 EGFR anti-tumor effect genome editing oncolytic virus out-of-frame

主题词遗传载体(Genetic Vectors);人类(Humans);肿瘤(Neoplasms);溶瘤病毒疗法(Oncolytic Virotherapy);溶瘤病毒(Oncolytic Viruses)

DOI 10.1016/j.ymthe.2020.07.003

PMID 32682455

发布时间 2024-08-02

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