首页> Bioorganic chemistry> Flavone inspired discovery of benzylidenebenzofuran-3(2H)-ones (aurones) as potent inhibitors of human protein kinase CK2.

Flavone inspired discovery of benzylidenebenzofuran-3(2H)-ones (aurones) as potent inhibitors of human protein kinase CK2.

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第一作者： M V,Protopopov

第一单位： Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine. Electronic address: mykola.protopopov@gmail.com.

作者： M V,Protopopov ^[1] ; V S,Vdovin ^[2] ; S A,Starosyla ^[2] ; I P,Borysenko ^[3] ; A O,Prykhod'ko ^[3] ; S S,Lukashov ^[2] ; Y V,Bilokin ^[4] ; V G,Bdzhola ^[2] ; S M,Yarmoluk ^[2]

作者单位： Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine. Electronic address: mykola.protopopov@gmail.com. ^[1] Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine. ^[2] Institute of Molecular Biology and Genetics, NAS of Ukraine, 150 Zabolotnogo St., 03143 Kyiv, Ukraine; LLC Scientific and Service Firm "Otava", 117/125 Borschagivska St., Suite 79, 03056 Kyiv, Ukraine. ^[3] OTAVA Ltd., 400 Applewood Crescent, Unit 100, Vaughan, Ontario L4K 0C3, Canada. ^[4]

关键词 2-benzylidenebenzofuran-3-ones Aurone In vitro biochemical assay Molecular docking Protein kinase CK2 inhibitor Virtual screening

医学主题词苯呋喃类(Benzofurans);酪蛋白激酶Ⅱ(Casein Kinase II);黄酮类(Flavones);人类(Humans);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.bioorg.2020.104062

PMID 32683178

发布时间 2021-03-18

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