Fructose-coated Angstrom silver inhibits osteosarcoma growth and metastasis via promoting ROS-dependent apoptosis through the alteration of glucose metabolism by inhibiting PDK.-论文-万方医学网

作者： Xiong-Ke,Hu ^[1] ; Shan-Shan,Rao ^[2] ; Yi-Juan,Tan ^[2] ; Hao,Yin ^[3] ; Ming-Jie,Luo ^[1] ; Zhen-Xing,Wang ^[2] ; Jin-Hua,Zhou ^[1] ; Chun-Gu,Hong ^[2] ; Zhong-Wei,Luo ^[3] ; Wei,Du ^[1] ; Ben,Wu ^[2] ; Zi-Qi,Yan ^[4] ; Ze-Hui,He ^[5] ; Zheng-Zhao,Liu ^[2] ; Jia,Cao ^[1] ; Yang,Wang ^[2] ; Wei-Yi,Situ ^[1] ; Hao-Ming,Liu ^[6] ; Jie,Huang ^[1] ; Yi-Yi,Wang ^[2] ; Kun,Xia ^[1] ; Yu-Xuan,Qian ^[2] ; Yan,Zhang ^[1] ; Tao,Yue ^[2] ; Yi-Wei,Liu ^[1] ; Hong-Qi,Zhang ^[2] ; Si-Yuan,Tang ^[7] ; Chun-Yuan,Chen ^[8] ; Hui,Xie ^[1]

作者单位： Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. ^[1] Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. ^[2] Xiangya School of Nursing, Central South University, Changsha, Hunan 410013, China. ^[3] Xiangya Hospital of Central South University - Amcan Pharmaceutical Biotechnology Co. Ltd. Joint Research Center, Changsha, Hunan 410008, China. ^[4] Department of Orthopedics, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, China. ^[5] Department of Rehabilitation, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. ^[6] Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. ^[7] National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. ^[8] Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. ^[9] Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. ^[10] Hunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Changsha, Hunan 410008, China. ^[11] Hunan Key Laboratory of Bone Joint Degeneration and Injury, Changsha, Hunan 410008, China. ^[12] Key Laboratory of Biological Nanotechnology of National Health Commission, Changsha, Hunan 410008, China. ^[13]

主题词青少年(Adolescent);动物(Animals);细胞凋亡(Apoptosis);骨肿瘤(Bone Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);顺铂(Cisplatin);女(雌)性(Female);果糖(Fructose);人类(Humans);婴儿(Infant);婴儿, 新生(Infant, Newborn);注射, 静脉内(Injections, Intravenous);肺肿瘤(Lung Neoplasms);男(雄)性(Male);金属纳米粒子(Metal Nanoparticles);小鼠(Mice);线粒体(Mitochondria);骨肉瘤(Osteosarcoma);氧化还原(Oxidation-Reduction);活性氧(Reactive Oxygen Species);信号传导(Signal Transduction);银(Silver);组织分布(Tissue Distribution);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays);青年人(Young Adult)

DOI 10.7150/thno.45858

PMID 32685015

发布时间 2021-05-05

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Fructose-coated Angstrom silver inhibits osteosarcoma growth and metastasis via promoting ROS-dependent apoptosis through the alteration of glucose metabolism by inhibiting PDK.

Theranostics

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Fructose-coated Angstrom silver inhibits osteosarcoma growth and metastasis via promoting ROS-dependent apoptosis through the alteration of glucose metabolism by inhibiting PDK.

Theranostics

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Theranostics

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