Aberrant DNA methylation results in altered gene expression in non-alcoholic steatohepatitis-related hepatocellular carcinomas.

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作者： Ying,Tian ^[1] ; Eri,Arai ^[2] ; Satomi,Makiuchi ^[1] ; Noboru,Tsuda ^[1] ; Junko,Kuramoto ^[1] ; Kentaro,Ohara ^[1] ; Yoriko,Takahashi ^[3] ; Nanako,Ito ^[1] ; Hidenori,Ojima ^[1] ; Nobuyoshi,Hiraoka ^[4] ; Masahiro,Gotoh ^[5] ; Teruhiko,Yoshida ^[5] ; Yae,Kanai ^[1]

作者单位： Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. ^[1] Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. earai@keio.jp. ^[2] Bioscience Department, Solution Knowledge Center, Mitsui Knowledge Industry Co., Ltd, Tokyo, 105-6215, Japan. ^[3] Pathology Division, Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, 104-0045, Japan. ^[4] Fundamental Innovative Oncology Core Center, National Cancer Center Research Institute, Tokyo, 104-0045, Japan. ^[5]

关键词 DCAF4L2 DNA methylation Expression alteration Hepatocellular carcinoma Non-alcoholic steatohepatitis

主题词癌, 肝细胞(Carcinoma, Hepatocellular);DNA甲基化(DNA Methylation);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);全基因组关联研究(Genome-Wide Association Study);人类(Humans);肝肿瘤(Liver Neoplasms);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction)

DOI 10.1007/s00432-020-03298-4

PMID 32685988

发布时间 2023-11-12

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