换一批Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.
第一作者：
Syed H,Zaidi
第一单位：
Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
作者：
Syed H,Zaidi [1]
;
Tabitha A,Harrison [2]
;
Amanda I,Phipps [2]
;
Robert,Steinfelder [2]
;
Quang M,Trinh [1]
;
Conghui,Qu [2]
;
Barbara L,Banbury [2]
;
Peter,Georgeson [3]
;
Catherine S,Grasso [4]
;
Marios,Giannakis [5]
;
Jeremy B,Adams [1]
;
Elizabeth,Alwers [6]
;
Efrat L,Amitay [6]
;
Richard T,Barfield [7]
;
Sonja I,Berndt [8]
;
Ivan,Borozan [1]
;
Hermann,Brenner [9]
;
Stefanie,Brezina [10]
;
Daniel D,Buchanan [11]
;
Yin,Cao [12]
;
Andrew T,Chan [13]
;
Jenny,Chang-Claude [14]
;
Charles M,Connolly [2]
;
David A,Drew [15]
;
Alton Brad,Farris [16]
;
Jane C,Figueiredo [17]
;
Amy J,French [18]
;
Charles S,Fuchs [19]
;
Levi A,Garraway [5]
;
Steve,Gruber [20]
;
Mark A,Guinter [21]
;
Stanley R,Hamilton [22]
;
Sophia,Harlid [23]
;
Lawrence E,Heisler [1]
;
Akihisa,Hidaka [2]
;
John L,Hopper [24]
;
Wen-Yi,Huang [8]
;
Jeroen R,Huyghe [2]
;
Mark A,Jenkins [25]
;
Paul M,Krzyzanowski [1]
;
Mathieu,Lemire [1]
;
Yi,Lin [2]
;
Xuemei,Luo [1]
;
Elaine R,Mardis [26]
;
John D,McPherson [27]
;
Jessica K,Miller [1]
;
Victor,Moreno [28]
;
Xinmeng Jasmine,Mu [5]
;
Reiko,Nishihara [29]
;
Nickolas,Papadopoulos [30]
;
Danielle,Pasternack [1]
;
Michael J,Quist [2]
;
Adilya,Rafikova [1]
;
Emma E G,Reid [1]
;
Eve,Shinbrot [31]
;
Brian H,Shirts [32]
;
Lincoln D,Stein [1]
;
Cherie D,Teney [1]
;
Lee,Timms [1]
;
Caroline Y,Um [21]
;
Bethany,Van Guelpen [33]
;
Megan,Van Tassel [1]
;
Xiaolong,Wang [2]
;
David A,Wheeler [31]
;
Christina K,Yung [1]
;
Li,Hsu [34]
;
Shuji,Ogino [35]
;
Andrea,Gsur [10]
;
Polly A,Newcomb [7]
;
Steven,Gallinger [36]
;
Michael,Hoffmeister [6]
;
Peter T,Campbell [21]
;
Stephen N,Thibodeau [18]
;
Wei,Sun [2]
;
Thomas J,Hudson [1]
;
Ulrike,Peters [37]
作者单位：
Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.
[1]
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.
[2]
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.;University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.
[3]
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.;Department of Surgery, Cedar Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.
[4]
Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.;Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA.
[5]
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
[6]
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA.
[7]
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
[8]
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.;Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.;German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[9]
Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Borschekagasse 8a, 1090, Vienna, Austria.
[10]
Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.;University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.;Genomic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, VIC, Australia.;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
[11]
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, Boston, MA, 02114, USA.;Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.;Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
[12]
Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA.;Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, Boston, MA, 02114, USA.;Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.;Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Avenue, Boston, MA, 02115, USA.;Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Avenue, Boston, MA, 02115, USA.
[13]
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.;Cancer Epidemiology Group, University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), 20246, Hamburg, Germany.
[14]
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, 100 Cambridge Street, Boston, MA, 02114, USA.;Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, 25 Shattuck Street, Boston, MA, 02115, USA.
[15]
Pathology and Laboratory Medicine, Emory University School of Medicine, 1364 Clifton Rd. NE, Atlanta, GA, 30322, USA.
[16]
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA.;Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
[17]
Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
[18]
Yale Cancer Center, 333 Cedar St, New Haven, CT, 06510, USA.;Department of Medicine, Yale School of Medicine, New Haven, CT, USA.;Smilow Cancer Hospital, New Haven, CT, USA.
[19]
Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA, 90089, USA.
[20]
Behavioral and Epidemiology Research Group, American Cancer Society, 250 Williams St NW, Atlanta, GA, 30303, USA.
[21]
City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA, 91010, USA.
[22]
Department of Radiation Sciences, Oncology Unit, Umeå University, SE-901 87, Umeå, Sweden.
[23]
University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC, 3010, Australia.
[24]
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3010, Australia.
[25]
Institute for Genomic Medicine, Nationwide Children's Hospital and The Ohio State University College of Medicine, 575 Children's Crossroad, Columbus, OH, 43215, USA.
[26]
Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.;Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, 2700 Stockton Blvd, Sacramento, CA, 95817, USA.
[27]
Oncology Data Analytics Program, Catalan Institute of Oncology and ONCOBELL Program, IDIBELL, Avinguda de la Granvia de l'Hospitalet 199-203, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.;CIBER Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.;Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, 08907, Barcelona, Spain.
[28]
Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.;Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
[29]
Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Institution, 1650 Orleans Street, Baltimore, MD, 21231, USA.
[30]
Human Genome Sequencing Centre, Baylor College of Medicine, One Baylor Plaza, Alkek N1419, Houston, TX, 77030, USA.
[31]
Department of Laboratory Medicine, University of Washington, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA, 98195, USA.
[32]
Department of Radiation Sciences, Oncology Unit, Umeå University, SE-901 87, Umeå, Sweden.;Wallenberg Centre for Molecular Medicine, Umeå University, SE-901 87, Umeå, Sweden.
[33]
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA.;Department of Biostatistics, University of Washington, Seattle, WA, USA.
[34]
Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA, 02142, USA.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, 677 Huntington Avenue, Boston, MA, 02115, USA.;Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.;Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
[35]
Ontario Institute for Cancer Research, 661 University Avenue, Toronto, ON, M5G 0A3, Canada.;Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.;Department of Surgery, University Health Network Toronto General Hospital, Toronto, ON, Canada.
[36]
Public Health Sciences Division, Fred Hutchinson Cancer Research Centre, 1100 Fairview Ave N, Seattle, WA, 98109, USA. upeters@fredhutch.org.;Department of Epidemiology, University of Washington, Seattle, WA, USA. upeters@fredhutch.org.
[37]
医学主题词
结肠肿瘤(Colonic Neoplasms);结直肠肿瘤(Colorectal Neoplasms);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);人类(Humans);INDEL突变(INDEL Mutation);突变(Mutation);肿瘤蛋白质类(Neoplasm Proteins);预后(Prognosis);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)
DOI
10.1038/s41467-020-17386-z
PMID
32686686
发布时间
2026-03-30
基金项目
R01 CA076366/CA/NCI NIH HHS/United States
P30 CA015704/CA/NCI NIH HHS/United States
U24 CA074783/CA/NCI NIH HHS/United States
U01 CA137088/CA/NCI NIH HHS/United States
U24 CA074794/CA/NCI NIH HHS/United States
U01 CA206110/CA/NCI NIH HHS/United States
R01 CA176272/CA/NCI NIH HHS/United States
U01 CA167551/CA/NCI NIH HHS/United States
UM1 CA186107/CA/NCI NIH HHS/United States
U01 CA074783/CA/NCI NIH HHS/United States
U01 CA164930/CA/NCI NIH HHS/United States
U01 CA074794/CA/NCI NIH HHS/United States
R01 CA223498/CA/NCI NIH HHS/United States
CIHR/Canada
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