Mechanisms underlying the cytotoxic activity of syn/anti-isomers of dinuclear Au(I) NHC complexes.

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作者： Bruno,Dominelli ^[1] ; Christian H G,Jakob ^[1] ; Jens,Oberkofler ^[1] ; Pauline J,Fischer ^[1] ; Eva-Maria,Esslinger ^[1] ; Robert M,Reich ^[1] ; Fernanda,Marques ^[2] ; Teresa,Pinheiro ^[3] ; João D G,Correia ^[2] ; Fritz E,Kühn ^[4]

作者单位： Faculty of Chemistry and Catalysis Research Center, Molecular Catalysis, Technische Universität München, Lichtenbergstr. 4, D-85748, Garching bei München, Germany. ^[1] Centro de Ciências e Tecnologias Nucleares and Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Estrada Nacional Nº 10 (km 139,7), 2695-066, Bobadela, LRS, Portugal. ^[2] IBB-Institute for Bioengineering and Biosciences and Departamento de Engenharia e Ciências Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001, Lisboa, Portugal. ^[3] Faculty of Chemistry and Catalysis Research Center, Molecular Catalysis, Technische Universität München, Lichtenbergstr. 4, D-85748, Garching bei München, Germany. Electronic address: fritz.kuehn@ch.tum.de. ^[4]

关键词 Antiproliferative activity Bridge-functionalized NHC Counter-anion exchange Dinuclear gold(I) complexes Syn and anti-isomers TrxR inhibition