Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension.

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作者： Junichi,Omura ^[1] ; Karima,Habbout ^[1] ; Tsukasa,Shimauchi ^[1] ; Wen-Hui,Wu ^[1] ; Sandra,Breuils-Bonnet ^[2] ; Eve,Tremblay ^[1] ; Sandra,Martineau ^[1] ; Valérie,Nadeau ^[1] ; Kassandra,Gagnon ^[1] ; Florence,Mazoyer ^[1] ; Jean,Perron ^[1] ; Francois,Potus ^[1] ; Jian-Hui,Lin ^[3] ; Hamza,Zafar ^[4] ; David G,Kiely ^[4] ; Allan,Lawrie ^[5] ; Stephen L,Archer ^[4] ; Roxane,Paulin ^[5] ; Steeve,Provencher ^[4] ; Olivier,Boucherat ^[3] ; Sébastien,Bonnet ^[1]

作者单位： Pulmonary Hypertension Research Group, Center de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, QC, Canada (J.O., K.H., T.S., W-H.W., S.B-B., E.T., S.M., V.N., K.G., F.M., J.P., R.P., S.P., O.B., S.B.). ^[1] Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, China (W-H.W.). ^[2] Department of Medicine, Queen's University, Kingston, ON, Canada (F.P., S.L.A.). ^[3] Department of Infection, Immunity and Cardiovascular Science, University of Sheffield, UK (J-H.L., H.Z., D.G.K., A.L.). ^[4] Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, UK (H.Z., D.G.K.). ^[5] Department of Medicine, Université Laval, Québec, QC, Canada (R.P., S.P., O.B., S.B.). ^[6]

关键词 fibrosis heart failure hemodynamics hypertrophy pulmonary arterial hypertension

主题词动物(Animals);心力衰竭(Heart Failure);人类(Humans);利钠肽, 脑(Natriuretic Peptide, Brain);肽碎片(Peptide Fragments);大鼠(Rats);心室功能障碍, 右(Ventricular Dysfunction, Right)

DOI 10.1161/CIRCULATIONAHA.120.047626

PMID 32698630

发布时间 2021-08-31

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准确一般字义偏差语意偏离译文作用小提交