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Light-Activated Carbon Monoxide Prodrugs Based on Bipyridyl Dicarbonyl Ruthenium(II) Complexes.

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第一作者： Stepan,Geri

第一单位： Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328, Dresden, Germany.

作者： Stepan,Geri ^[1] ; Tereza,Krunclova ^[2] ; Olga,Janouskova ^[2] ; Jiri,Panek ^[3] ; Martin,Hruby ^[3] ; Daniel,Hernández-Valdés ^[4] ; Benjamin,Probst ^[4] ; Roger A,Alberto ^[4] ; Constantin,Mamat ^[1] ; Manja,Kubeil ^[1] ; Holger,Stephan ^[1]

作者单位： Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, 01328, Dresden, Germany. ^[1] Department of Biological Models, Institute of Macromolecular Chemistry, Heyrovsky Square 2, 16206, Prague, Czech Republic. ^[2] Supramolecular Polymer Systems, Institute of Macromolecular Chemistry, Heyrovsky Square 2, 16206, Prague, Czech Republic. ^[3] Department of Chemistry, University of Zurich, Winterthurerstr. 190, 8057, Zurich, Switzerland. ^[4]

关键词 anti-apoptotic activity anti-proliferative cellular localisation photoCORM ruthenium(II)

医学主题词 2,2'-联吡啶(2,2'-Dipyridyl);一氧化碳(Carbon Monoxide);细胞系, 肿瘤(Cell Line, Tumor);HEK293细胞(HEK293 Cells);人类(Humans);药物前体(Prodrugs);钌(Ruthenium)

DOI 10.1002/chem.202002139

PMID 32700815

发布时间 2023-11-12

基金项目

627113/ Marie-Curie Actions/FP7 People 19-01438S/Czech Science Foundation 57448291/Deutscher Akademischer Austauschdienst

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