换一批A Novel Methoxybenzyl 5-Nitroacridone Derivative Effectively Triggers G1 Cell Cycle Arrest in Chronic Myelogenous Leukemia K562 Cells by Inhibiting CDK4/6-Mediated Phosphorylation of Rb.
第一作者：
Bin,Zhang
第一单位：
Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Department of Marine Pharmacy, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315800, Zhejiang, China.;State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China.
作者：
主题词
抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);半胱氨酸天冬氨酸蛋白酶(Caspases);细胞增殖(Cell Proliferation);色谱法, 液相(Chromatography, Liquid);细胞周期蛋白依赖激酶4(Cyclin-Dependent Kinase 4);细胞周期蛋白依赖激酶6(Cyclin-Dependent Kinase 6);人类(Humans);K562细胞(K562 Cells);白血病, 髓系, 慢性, BCR-ABL阳性(Leukemia, Myelogenous, Chronic, BCR-ABL Positive);质谱分析法(Mass Spectrometry);代谢组学(Metabolomics);磷酰化(Phosphorylation);视网膜母细胞瘤蛋白质(Retinoblastoma Protein);信号传导(Signal Transduction)
DOI
10.3390/ijms21145077
PMID
32708403
发布时间
2021-03-05
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