What is the optimal loading dose of broad-spectrum β-lactam antibiotics in septic patients? Results from pharmacokinetic simulation modelling.

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作者： Isabelle K,Delattre ^[1] ; Maya,Hites ^[2] ; Pierre-Francois,Laterre ^[3] ; Thierry,Dugernier ^[4] ; Herbert,Spapen ^[5] ; Pierre E,Wallemacq ^[6] ; Frédérique,Jacobs ^[2] ; Fabio Silvio,Taccone ^[7]

作者单位： Louvain Centre for Toxicology and Applied Pharmacology, Université Catholique de Louvain (UCL), Brussels, Belgium; Louvain Drug Research Institute, Université Catholique de Louvain (UCL), Brussels, Belgium. ^[1] Department of Infectious Diseases, Cliniques Universitaires de Bruxelles Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium. ^[2] Department of Intensive Care, Cliniques Universitaires St Luc, Université Catholique de Louvain (UCL), Brussels, Belgium. ^[3] Department of Intensive Care, Clinique St-Pierre, Ottignies, Belgium. ^[4] Department of Intensive Care, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium. ^[5] Louvain Centre for Toxicology and Applied Pharmacology, Université Catholique de Louvain (UCL), Brussels, Belgium. ^[6] Department of Intensive Care, Cliniques Universitaires de Bruxelles Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium. Electronic address: ftaccone@ulb.ac.be. ^[7]

关键词 Loading dose Monte Carlo simulation Pharmacokinetics Sepsis β-Lactams