Molecular basis for the inhibitory effects of 5-hydroxycyclopenicillone on the conformational transition of Aβ<sub>40</sub> monomer.

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作者： Huitu,Zhang ^[1] ; Jingcheng,Sang ^[1] ; Li,Li ^[2] ; Luying,Jiang ^[1] ; Fuping,Lu ^[1] ; Shan,He ^[3] ; Wei,Cui ^[4] ; Xiaoqing,Zhang ^[4] ; Fufeng,Liu ^[1]

作者单位： State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education; Tianjin Key Laboratory of Industrial Microbiology; College of Biotechnology, Tianjin University of Science & Technology, Tianjin, P. R. China. ^[1] College of Marine and Environmental Sciences, Tianjin University of Science & Technology, Tianjin, P. R. China. ^[2] Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo, China. ^[3] Ningbo Key Laboratory of Behavioral Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China. ^[4]

关键词 Amyloid-β peptide molecular dynamics simulation small molecular inhibitor

主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);人类(Humans);分子构象(Molecular Conformation);分子动力学模拟(Molecular Dynamics Simulation);肽碎片(Peptide Fragments)

DOI 10.1080/07391102.2020.1799863

PMID 32723218

发布时间 2021-10-22

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