The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33.

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第一作者： M,Liguori

第一单位： IRCCS Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, MI, Italy.

作者： M,Liguori ^[1] ; E,Digifico ^[2] ; A,Vacchini ^[3] ; R,Avigni ^[1] ; F S,Colombo ^[1] ; E M,Borroni ^[3] ; F M,Farina ^[1] ; S,Milanesi ^[3] ; A,Castagna ^[3] ; L,Mannarino ^[4] ; I,Craparotta ^[4] ; S,Marchini ^[4] ; E,Erba ^[4] ; N,Panini ^[4] ; M,Tamborini ^[3] ; V,Rimoldi ^[1] ; P,Allavena ^[5] ; C,Belgiovine ^[6]

作者单位： IRCCS Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, MI, Italy. ^[1] Department of Biomedical Sciences, Humanitas University, via Rita Levi Montalcini 4, 20089, Pieve Emanuele, Italy. ^[2] IRCCS Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, MI, Italy.;Department of Medical Biotechnologies and Translational Medicine, Università degli Studi di Milano, Via Fratelli Cervi, 20090, Segrate, Italy. ^[3] Department of Oncology, Mario Negri Institute for Pharmacological Research IRCCS, 20156, Milan, Italy. ^[4] IRCCS Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, MI, Italy. paola.allavena@humanitasresearch.it. ^[5] IRCCS Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, MI, Italy. Cristina.belgiovine@humanitasresearch.it. ^[6]

关键词 GPNMB IL-33 cancer stem cells metastasis tumor associated macrophages

主题词动物(Animals);细胞凋亡(Apoptosis);细胞增殖(Cell Proliferation);纤维肉瘤(Fibrosarcoma);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);肺肿瘤(Lung Neoplasms);巨噬细胞(Macrophages);男(雄)性(Male);膜糖蛋白类(Membrane Glycoproteins);小鼠(Mice);小鼠, 近交DBA(Mice, Inbred DBA);肿瘤干细胞(Neoplastic Stem Cells);肉瘤, 实验性(Sarcoma, Experimental);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1038/s41423-020-0501-0

PMID 32728200

发布时间 2022-04-22

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Cellular & molecular immunology

2021年18卷3期

711-722页

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The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33.

Cellular & molecular immunology

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Cellular & molecular immunology

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The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33.

Cellular & molecular immunology

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Cellular & molecular immunology

相关期刊

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